Targeted therapy with bevacizumab and erlotinib tailored to the molecular profile of patients with recurrent glioblastoma. Preliminary experience

QG D'Alessandris, N Montano, T Cenci, M Martini… - Acta …, 2013 - Springer
… treatment to more than one pathway should provide therapeutic advantages [… preliminary
experience of targeted therapy with bevacizumab and erlotinib tailored to the molecular profile

Eight-year survival of a recurrent glioblastoma patient treated with molecularly tailored therapy: a case report

QG D'Alessandris, N Montano, M Martini, T Cenci… - Acta …, 2018 - Springer
molecular screening for personalization of targeted therapy in … a patient suffering from
recurrent GBM who was treated with bevacizumab and erlotinib tailored to the molecular profile of …

A single-institution phase II trial of radiation, temozolomide, erlotinib, and bevacizumab for initial treatment of glioblastoma

JL Clarke, AM Molinaro, JJ Phillips… - Neuro …, 2014 - academic.oup.com
… came into common use for recurrent GBM at many academic … Continued effort to tailor treatment
by molecular profile will … Preliminary results for this study were presented in abstract form …

… -41. PROSPECTIVE SELECTION OF RECURRENT GLIOBLASTOMA PATIENTS FOR TAILORED THERAPIES. RESULTS OF AN INSTITUTIONAL EXPERIENCE

Q Giorgio D'Alessandris, N Montano, M Martini… - Neuro …, 2019 - academic.oup.com
… of GBM treatment on the horizon are targeted therapy utilizing … In preliminary studies, we
prospectively selected recurrent … ), 14 bevacizumab plus erlotinib (bev+erl) and 4 bevacizumab

[PDF][PDF] Updates in Genetic Molecular Targeted Therapy for Glioblastoma

BA Abdelmaksoud - Cancer and Oncology Research, 2016 - academia.edu
gliomas and to evaluat the efficacy of vorinostat + erlotinibbevacizumab alone or in
combination with irinotecan was well tolerated and effective in patients with recurrent glioblastoma […

[HTML][HTML] Glioblastoma targeted therapy: updated approaches from recent biological insights

M Touat, A Idbaih, M Sanson, KL Ligon - Annals of Oncology, 2017 - Elsevier
… EGFR tyrosine kinase inhibitors (TKI) erlotinib and gefitinb [45, 46]. … plus bevacizumab
in EGFRvIII-positive recurrent glioblastoma. … Preliminary data from a phase I trial of ABT-414 …

New directions in the therapy of glioblastoma

K Szklener, M Mazurek, M Wieteska, M Wacławska… - Cancers, 2022 - mdpi.com
… approved bevacizumab as a single agent for recurrent GBM … study, patients with progressive
or recurrent GBM received erlotinib (… ) showed the promising preliminary antitumor activity of …

Lessons learned in the development of targeted therapy for malignant gliomas

AMP Omuro, S Faivre, E Raymond - Molecular cancer therapeutics, 2007 - AACR
… (rapamycin) combined with gefitinib, erlotinib, or AEE788. A … in unselected recurrent
glioblastoma patients were recently … bevacizumab combined with irinotecan in malignant gliomas

[PDF][PDF] Targeted therapy of glioblastomas: a 5-year view

R Djedid, R Kiss - Clinical Practice, 2009 - researchgate.net
… II study of erlotinib in patients with recurrent EGFR‑ positive … Three Phase II trials are currently
ongoing using bevacizumab … ongoing trials targeting PDGFR for recurrent GBM patients. …

Molecularly targeted therapies for malignant glioma: rationale for combinatorial strategies

NG Thaker, IF Pollack - Expert review of neurotherapeutics, 2009 - Taylor & Francis
… of imatinib in recurrent gliomas, and preliminary results showed … of sorafenib and erlotinib
for patients with recurrent GBM, … comparing the effect of bevacizumab alone or in combination …